They go along nicely with Microsoft’s 2GB mailbox recommendations. Warning at 1.89GB, Prohibit Send at 2GB and Prohibit Send/Receive at 2.29GB. Personally I’m a fan of much smaller mailboxes for enterprise but I’ve got the defaults currently in place on my home Exchange 2007 server. I think it will be OK with the 5 mailboxes on it. 
One thing to keep in mind (that a number of people miss) is to stagger these limits. If you set all the limits to 1GB, you’re going to have issues when users start asking why they didn’t get warned and all of a sudden couldn’t send mail. For example, if you want to give 1GB mailboxes do something like Issue warning at 900MB, Prohibit send at 1GB and Prohibit send and receive at 1.1GB.
The numbers themselves are up to you (except for performance issues which I will go over in a later post), but the important thing is to stagger them. This will give your users time to clean out their mailboxes and no excuse to complain.
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